David Macko was born in Cleveland, Ohio, in 1942, graduated from John Adams High School in 1960 and from Adelbert College of what is now Case Western Reserve University in 1964. He served in the US Army from 1966 to 1968, sold insurance and was an adjustor at several institutions before working at Key Bank for 28 years. He retired in 2001.

He has been a member of the Libertarian Party since 1980 and a Life Member since 1988. He is also a Life Member of the John Birch Society, the Gun Owners of America and Jews For The Preservation of Firearms and the American Legion. Other memberships include the NRA, Veterans For Peace, Campaign for Liberty, the National Taxpayers Association and the Burton 9-12 Group.

He was a Region Representative or Chairman of the Libertarian Party of Northeast Ohio most of the time from 1988 to 2008.

In 2008 he ran for Congress as a Libertarian against Steve LaTourette and William O'Neill. In 1972 he was an American Party candidate for State Representative. He has attended all Libertarian National Conventions since 1987.

He attends Archangel Michael Orthodox Church in Broadview Heights.